Introduction
Miracal-D is a prescription medicine. It is a combination of medicines that are prescribed to treat osteoporosis. It ensures the proper growth and functioning of the joints and bones. Miracal-D should be used in the dose and duration as prescribed by your doctor. It is advised to take this medicine at a fixed time. This medicine should not be taken in more than the recommended dose. This is usually a safe medicine with very minimal side effects but if you experience severe diarrhea, nausea, or vomiting or any symptoms of an allergic reaction, please consult your doctor. Before taking this medicine, tell your doctor if you have any other health conditions. Inform your doctor if you are taking any other medicines or if you are pregnant or breastfeeding.
Uses of Miracal-D
Pharmacology
Miracal-D is a combination of two nutritional supplements: Calcium and Vitamin D3 which replenish the body's stores of important nutrients.
Composion:
KcitTM 200 ml oral solution: Each 5 ml solution contains Potassium Citrate BP 1500 mg and Citric Acid
Monohydrate BP 250 mg
Pharmacology:
Potassium Citrate and Citric Acid Monohydrate oral solution is a stable and pleasant-tasting oral systemic
alkalizer. Potassium Citrate is absorbed and metabolized to Potassium Bicarbonate, thus as a
systemic alkalizer. This product alkalinizes the urine without producing a systemic alkalosis in
recommended doses. Potassium Citrate does not neutralize the gastric juice or disturb digestion.
Indications:
- To relieve discomfort in urinary tract infections
-To prevent kidney stone With uricosuric agent to prevent gout
- Acidosis caused by kidney diseases
Dose & Administration
By mouth using oral solution
Adult: 10 mL 3 times a day, diluted well with water
Or as directed by the physician.
Indications
Magnesium Oxide is indicated in-
Pharmacology
Magnesium belongs to the group of drugs called mineral support products. It occurs in nature in the form of the mineral periclase. Magnesium is required for energy production, oxidative phosphorylation, and glycolysis. In its purest form, magnesium oxide is a colorless or white crystalline material or very fine powder, with no odor and a bitter taste.
Magnesium helps to regulate diverse biochemical reactions in the body, including protein synthesis, muscle and nerve function, blood glucose control, and blood pressure regulation. It contributes to the structural development of bone and is required for the synthesis of DNA, RNA, and the antioxidant glutathione. Magnesium also plays a role in the active transport of calcium and potassium ions across cell membranes, a process that is important to nerve impulse conduction, muscle contraction, and normal heart rhythm.
Excretion
The majority of magnesium is excreted renally.
Dosage & Administration
The recommended daily dose for adults and adolescents (12-17 years) is 1-2 tablets.
Interaction
Aminoquinolones, Nitrofurantoin, Penicillamine, Tetracyclines, Fluoroquinolones, Digoxin, Lithium, Sodium polystyrene sulfonate, Nifedipine etc.
Contraindications Hypersensitivity and severe renal impairment.
Side Effects
Pregnancy & Lactation
It should be used as directed by the physician during pregnancy and lactation.
Precautions & Warnings
Before taking a magnesium supplement, tell your doctor or pharmacist if you are allergic to it.
Overdose Effects
Symptoms of overdose may include slow heartbeat, severe dizziness, confusion, muscle weakness, loss of consciousness, diarrhea and hypermagnesemia.
Therapeutic Class
Antacids, Electrolytes preparations, Oral electrolytes preparations
Storage Conditions
Keep out of reach of children. Store in a dry place, below 25°C temperature, and protected Irom light.
Administration:
Maybe taken with or without food
Mode of Action
Vitamin C: Necessary for collagen formation and tissue repair; plays a role in oxidation/reduction reactions as well as other metabolic pathways including synthesis of catecholamines, carnitine, and steroids; also plays a role in conversion of folic acid to folinic acid.
Precaution
Should be given with caution to patient with hyperoxaluria.
Side Effect
Flushing, Flank pain, Faintness, headache, Diarrhea, dyspepsia, nausea, vomiting, Hyperoxaluria (large doses)
Interaction
Vit C: Deferroxamine, hormonal contraceptives, flufenazine, warfarin, elemental iron, salicylates, warfarin, fluphenazine, disulfiram, mexiletine, vitamin B12.
Composition
Malifa 30:
Each capsule contains Ferric Maltol INN
equivalent to Iron 30 mg.
Pharmacology
Ferric Maltol delivers iron for uptake across the intestinal
wall and transfers to transferrin and ferritin. It has been
shown to increase serum iron parameters, including ferritin
and transferrin saturation. Ferric Maltol dissociates upon
uptake from the Gastrointestinal Tract allowing iron and
maltol to be absorbed separately. The iron is absorbed
across the intestinal wall and transfer to transferrin and
ferritin. It increases serum iron parameters, including ferritin
and transferrin saturation.
Total serum iron peak values were reached 1.5 to 3 hours
after administration. Food has been shown to decrease the
bioavailability of iron after administration of ferric maltol.
Around 60% of ferric maltol is excreted in the urine as
glucuronide conjugate. Iron and ferric maltol are not
excreted in the urine and unabsorbed ferric maltol is
eliminated in the feces.
Indications
It is indicated for the treatment of iron deficiency in adults.
Dosage & Administration
30 mg twice daily on an empty stomach (Morning &
Evening).
• Continue as long as necessary to replenish body iron
stores or as directed by the physician.
Contraindications
It is contraindicated in patients with a history of:
• Hypersensitivity to the active substance or to any of the
excipients.
• Hemochromatosis and other iron overload syndromes
• Receiving repeated blood transfusions.
Warnings & Precautions
Avoid use of Ferric Maltol in patients with an active
inflammatory bowel disease (IBD) flare, as there is potential
risk of increased inflammation in the gastrointestinal tract.
• Excessive therapy with iron drugs can lead to excess
storage of iron with the possibility of iatrogenic
hemosiderosis.
• Accidental overdose of iron-containing drugs is a leading
cause of fatal poisoning in children under 6 years.
Side Effects
The most common side effects include gas, diarrhoea,
constipation, discolored stools, stomach pain, nausea or
vomiting and stomach area discomfort or bloating.
Use in Pregnancy & Lactation
In a clinical study, it has been found that oral use of Ferric
Iron in pregnant women indicate no malformative nor feto
toxicity. Ferric Maltol may be considered during pregnancy
if necessary.
There is no effects of oral Ferric Iron in breastfeed
newborns or infants of treated mother. Ferric Maltol can be
used during breastfeeding if clinically needed.
Use in Children & Adolescents
Safety and effectiveness of Ferric Maltol have not been
established in paediatric patients.
Drug Interactions
Dimercaprol: Concomitant use of iron products with
dimercaprol may increase the risk of nephrotoxicity.
The absorption of certain oral medications decreases such
as bisphosphonates, levodopa, thyroid medications and
tetracycline antibiotics when given together with iron.
Overdosage
Early signs and symptoms of iron overdosage may include
nausea, vomiting, abdominal pain and diarrhoea. In more
serious cases, hypoperfusion, metabolic acidosis and
systemic toxicity are observed. Dosages of excess iron may
lead to hemosiderosis.
Storage
Store below 30°C, away from light and in a dry place. Keep
all medicines out of reach of children.