Methebac

Composition

Methebac Tablet: Each tablet contains Methenamine Hippurate USP 1 g.

Indications

Methebac is indicated for prophylactic or suppressive treatment of frequently recurring urinary tract infections when long-term therapy is considered necessary. This drug should only be used after eradication of the infection by other appropriate antimicrobial agents. 

Dosage & Administration

1 tablet (1.0 g) twice daily (morning and night) for adults and paediatric patients over 12 years of age. 1/2 to 1 tablet (0.5 to 1.0 g) twice daily (morning and night) for paediatric patients 6 to 12 years of age. Since the antibacterial activity of Methebac is greater in acid urine, restriction of alkalinizing foods and medications is desirable or as directed by the physician

Myobac

Composition: MyobacTM 5 Tablet : Each tablet contains Baclofen USP 5 mg. MyobacTM 10 Tablet : Each tablet contains Baclofen USP 10 mg.

Pharmacology: MyobacTM (Baclofen) is an effective muscle relaxant and antispastic agent with a spinal site of action. It exerts its action by inhibiting both monosynaptic and polysynaptic transmission in the spinal cord by stimulating GABAB receptors.

Indications: MyobacTM (Baclofen) is indicated for the alleviation of spasticity resulting from multiple sclerosis particularly for the relief of flexor spasm and concomitant pain, clonus and muscular rigidity, spinal cord diseases, muscle spasm of cerebral origin especially infantile cerebral palsy, stroke or neoplastic or degenerative brain diseases. It may be of some value in patients with trigeminal neuralgia, tardive dyskinesia, cluster headache & tension type headache.

Dosage & Administration: Muscle relaxant & spasticity For adults: Start at a low dosage and increase gradually until the optimum effect is achieved (usually 40-80mg daily). Initially 5 mg three times daily for 3 days; then 10 mg three times daily for 3 days, 15 mg three times daily for 3 days and 20 mg three times daily for 3 days. Additional increases in dose may be required but should not exceed 20 mg four times daily. For Children: (treatment of spasticity): 0.75-2 mg/kg daily (over 10 years, max. 2.5 mg/kg daily) or 2.5 mg 4 times daily increased gradually according to age to maintenance: 1-2 years 10-20 mg daily, 2-6 years 20-30 mg daily, 6-10 years 30-60 mg daily. Or as directed by the physician. Contraindications: MyobacTM (Baclofen) is contraindicated in patients who are hypersensitive to any component of this preparation. Warning and precaution: Hallucinations and seizures may occur on abrupt withdrawal of MyobacTM (Baclofen). Therefore, except for serious adverse reactions, the dose should be reduced slowly when the drug is discontinued. Side effects: Common side effects: Agitation, anxiety, ataxia, cardiovascular depression, confusion, depression, dizziness, drowsiness, dry mouth, euphoria, gastrointestinal disturbances, hallucinations, headache, hypotension, insomnia and myalgia. Rare side effects: Abdominal pain, changes in hepatic function, c, paraesthesia and taste disturbances.

Momespray

Miracal-D

Introduction

Miracal-D is a prescription medicine. It is a combination of medicines that are prescribed to treat osteoporosis. It ensures the proper growth and functioning of the joints and bones. Miracal-D should be used in the dose and duration as prescribed by your doctor. It is advised to take this medicine at a fixed time. This medicine should not be taken in more than the recommended dose. This is usually a safe medicine with very minimal side effects but if you experience severe diarrhea, nausea, or vomiting or any symptoms of an allergic reaction, please consult your doctor. Before taking this medicine, tell your doctor if you have any other health conditions. Inform your doctor if you are taking any other medicines or if you are pregnant or breastfeeding.

Uses of Miracal-D

• Nutritional deficiencies

Pharmacology

Miracal-D is a combination of two nutritional supplements: Calcium and Vitamin D3 which replenish the body's stores of important nutrients.

MegaMag

Indications

Magnesium Oxide is indicated in-

• Relieving the symptoms of magnesium deficiency.
• Rapid or irregular heart rate, heart attack, angina pectoris, mild or severe hypertension.
• Tetania, muscle cramp, gastrointestinal cramps, stress, increased stimulability of muscles and nerves, call cramps, and cramp in newborn and young children.
• Gynecological diseases, cervical insufficiency, eclampsia, pre-eclampsia, tocolysis, dysmenorrhea.
• Calcification and ossification
• Prevention of kidney stone formation
• Diabetes treatment and migraine

Pharmacology

Magnesium belongs to the group of drugs called mineral support products. It occurs in nature in the form of the mineral periclase. Magnesium is required for energy production, oxidative phosphorylation, and glycolysis. In its purest form, magnesium oxide is a colorless or white crystalline material or very fine powder, with no odor and a bitter taste.

Magnesium helps to regulate diverse biochemical reactions in the body, including protein synthesis, muscle and nerve function, blood glucose control, and blood pressure regulation. It contributes to the structural development of bone and is required for the synthesis of DNA, RNA, and the antioxidant glutathione. Magnesium also plays a role in the active transport of calcium and potassium ions across cell membranes, a process that is important to nerve impulse conduction, muscle contraction, and normal heart rhythm.

Excretion

 The majority of magnesium is excreted renally.

Dosage & Administration

The recommended daily dose for adults and adolescents (12-17 years) is 1-2 tablets.

Interaction

Aminoquinolones, Nitrofurantoin, Penicillamine, Tetracyclines, Fluoroquinolones, Digoxin, Lithium, Sodium polystyrene sulfonate, Nifedipine etc.

Contraindications Hypersensitivity and severe renal impairment.

Side Effects

• Stomach upset and diarrhea
• Hypermagnesaemia
• Paralytic ileus
• Hyper-excitability
• Muscle weakness
• Sleepiness
  
  

Pregnancy & Lactation

It should be used as directed by the physician during pregnancy and lactation.

Precautions & Warnings 
Before taking a magnesium supplement, tell your doctor or pharmacist if you are allergic to it.

Overdose Effects

Symptoms of overdose may include slow heartbeat, severe dizziness, confusion, muscle weakness, loss of consciousness, diarrhea and hypermagnesemia.

Therapeutic Class

Antacids, Electrolytes preparations, Oral electrolytes preparations

Storage Conditions

Keep out of reach of children. Store in a dry place, below 25°C temperature, and protected Irom light.

Malifa

Composition Malifa 30:
Each capsule contains Ferric Maltol INN equivalent to Iron 30 mg.

Pharmacology
Ferric Maltol delivers iron for uptake across the intestinal wall and transfers to transferrin and ferritin. It has been shown to increase serum iron parameters, including ferritin and transferrin saturation. Ferric Maltol dissociates upon uptake from the Gastrointestinal Tract allowing iron and maltol to be absorbed separately. The iron is absorbed across the intestinal wall and transfer to transferrin and ferritin. It increases serum iron parameters, including ferritin and transferrin saturation. Total serum iron peak values were reached 1.5 to 3 hours after administration. Food has been shown to decrease the bioavailability of iron after administration of ferric maltol. Around 60% of ferric maltol is excreted in the urine as glucuronide conjugate. Iron and ferric maltol are not excreted in the urine and unabsorbed ferric maltol is eliminated in the feces.

 Indications
It is indicated for the treatment of iron deficiency in adults.

Dosage & Administration 
 30 mg twice daily on an empty stomach (Morning & Evening). • Continue as long as necessary to replenish body iron stores or as directed by the physician.

Contraindications
It is contraindicated in patients with a history of: • Hypersensitivity to the active substance or to any of the excipients. • Hemochromatosis and other iron overload syndromes • Receiving repeated blood transfusions.

Warnings & Precautions
Avoid use of Ferric Maltol in patients with an active inflammatory bowel disease (IBD) flare, as there is potential risk of increased inflammation in the gastrointestinal tract. • Excessive therapy with iron drugs can lead to excess storage of iron with the possibility of iatrogenic hemosiderosis. • Accidental overdose of iron-containing drugs is a leading cause of fatal poisoning in children under 6 years.

Side Effects
The most common side effects include gas, diarrhoea, constipation, discolored stools, stomach pain, nausea or vomiting and stomach area discomfort or bloating.

Use in Pregnancy & Lactation
In a clinical study, it has been found that oral use of Ferric Iron in pregnant women indicate no malformative nor feto toxicity. Ferric Maltol may be considered during pregnancy if necessary. There is no effects of oral Ferric Iron in breastfeed newborns or infants of treated mother. Ferric Maltol can be used during breastfeeding if clinically needed.
Use in Children & Adolescents
Safety and effectiveness of Ferric Maltol have not been established in paediatric patients.

Drug Interactions
Dimercaprol: Concomitant use of iron products with dimercaprol may increase the risk of nephrotoxicity. The absorption of certain oral medications decreases such as bisphosphonates, levodopa, thyroid medications and tetracycline antibiotics when given together with iron.

Overdosage
Early signs and symptoms of iron overdosage may include nausea, vomiting, abdominal pain and diarrhoea. In more serious cases, hypoperfusion, metabolic acidosis and systemic toxicity are observed. Dosages of excess iron may lead to hemosiderosis.

Storage
Store below 30°C, away from light and in a dry place. Keep all medicines out of reach of children.

Momespray

Composition:

Momespray™: Each spray contains Mometasone Furoate BP 50 meg.

Indication:

Momespray™ is indicated for the treatment of the nasal symptoms of seasonal and perennial allergic rhinitis, in adults and pediatric patients 2 years of age and older. It

is indicated for the prophylaxis of the nasal symptoms of seasonal allergic rhinitis in adult and adolescent patients 12 years and older. It is also indicated for the treatment of

nasal polyps in patients 18 years and older.

Dose & Administration:

Administer Mometasone Nasal Spray by the intranasal route only.

Allergic Rhinitis

Adults and Children 12 Years of Age and Older: For prophylaxis and treatment of the nasal symptoms of seasonal allergic rhinitis and treatment of the nasal

symptoms of perennial allergic rhinitis use two sprays (50 meg of Mometasone Furoate in each spray) in each nostril once daily (total daily dose of 100 meg). In patients

with a known seasonal allergen that precipitates nasal symptoms of seasonal allergic rhinitis, prophylaxis use Momespray™ 50 meg (200 meg/day) 2 to 4 weeks prior

to the anticipated start of the pollen season.

Children (2 to 11 years of age) For treatment of the nasal symptoms of seasonal and perennial allergic rhinitis use one spray (50 meg of Mometasone Furoate in each spray) in each nostril once daily (total daily dose of 100 meg).

Nasal Polyps

Adults 18 years of Age and Older: For nasal polyps use two sprays (50 meg of Mometasone Furoate in each spray) in each nostril twice daily (total daily dose of 400

meg). A dose of two sprays (50 meg of mometasone furoate in each spray) in each nostril once daily (total daily dose of 200 meg) is also effective in some patients.

Meltix