Nabuton
Composition : Nabuton 500 Tablet: Each film coated tablet contains Nabumetone BP 500 mg.
Nabuton 750 Tablet: Each film coated tablet contains Nabumetone BP 750 mg.
Pharmacology: Nabumetone is a non-steroidal anti-inflammatory drug (NSAID) that exhibits anti-inflammatory,
analgesic and antipyretic properties in pharmacological studies. As with other non-steroidal
anti-inflammatory agents, it's mode of action is not known; however, the ability to inhibit
prostaglandin synthesis may be involved in the anti-inflammatory effect. The active ingredient is a
prodrug, which undergoes hepatic biotransformation to the active component,
6-methoxy-2-naphthylacetic acid (6MNA), that is a potent inhibitor of prostaglandin synthesis.
Indication:
Nabuton tablet is indicated for acute and chronic treatment of signs and symptoms of osteoarthritis
and rheumatoid arthritis.
Dose & Administration :Osteoarthritis and Rheumatoid arthritis: The recommended starting dose is 1000 mg taken as a
single dose with or without food. Some patients may obtain more symptomatic relief from 1500 mg to
2000 mg per day. Nabumetone can be given in either a single or twice-daily dose. Dosage greater
than 2000 mg per day have not been studied. The lowest effective dose should be used for chronic
treatment. Caution should be used in prescribing Nabumetone to patient with moderate or severe
renal insufficiency. The maximum starting dose of Nabumetone in patients with moderate or severe
renal insufficiency should not exceed 750 mg or 500 mg, respectively once daily. Following careful
monitoring of renal function in patients with moderate or severe renal insufficiency, daily doses may
be increased to a maximum of 1500 mg and 1000 mg, respectively or as directed by the
physicians.
Contraindication : Hypersensitivity NSAID induced asthma, urticaria or other allergic type reactions.
Naviscon
Composition
Naviscon Suspension: Each 10 ml suspension contains Sodium Alginate BP 500 mg, Sodium Bicarbonate BP 267 mg & Calcium Carbonate USP 160 mg. Naviscon Chewable Tablet: Each chewable tablet contains Sodium Alginate BP 250 mg, Sodium Bicarbonate BP 133.5 mg & Calcium Carbonate USP 80 mg.
Pharmacology
The mode of action of the product is non-systemic and does not depend on absorption into the systemic circulation. On ingestion, the product reacts rapidly with gastric acid to form a raft of Alginic acid gel having a near-neutral pH and which floats on the stomach contents quickly and effectively impeding gastro-esophageal reflux, for up to 4 hours. In severe cases, the raft itself may be refluxed into the esophagus in preference to the stomach contents and exert a demulcent effect. Indications Naviscon is indicated for the treatment of heartburn, heartburn of pregnancy, dyspepsia associated with gastric reflux, hiatus hernia, reflux esophagitis, regurgitation and all cases of epigastric and retrosternal distress where the underlying cause is gastric reflux.
Dosage & Administration
Naviscon Suspension: Adult and children over 12 years: 10-20 ml after meals and at bedtime, up to four times a day. Children 6 to 12 years: 5-10 ml after meals and at bedtime, up to four times a day. Children under 6 years: Not recommended. shake well before each use. Chewable Tablet: Adult and children over 12 years: 2-4 tablets after meals and at bedtime, up to four times a day. Children under 12 years: Should be given only on doctor advice. Elderly: No dosage modification is required for this age group. Hepatic Impairment: No dose modification necessary.
Contraindication
This product is contraindicated in patients with known or suspected hypersensitivity to the active ingredients or to any of the excipients.
Warnings & Precautions
If symptoms do not improve after 7 days, the clinical situation should be reviewed. This should be taken into account when a highly restricted salt diet is recommended e.g. in some cases of congestive cardiac failure and renal impairment. Care needs to be taken in treating patients with hypercalcaemia, nephrocalcinosis and recurrent calcium containing renal calculi.
Side Effects
In addition to the desired effect of the drug, some side effects may appear such as constipation, flatulence, stomach cramp or belching. If too big dose has been taken, there might appear a sensation of swelling in stomach. In these cases consult a physician.
N-bion
Composition
N-bion Tablet: Each tablet contains Thiamine Mononitrate USP 100 mg, Pyridoxine Hydrochloride BP 200 mg & Cyanocobalamin BP 200 meg.
Indication:
N-bion is indicated for the treatment of B1 , B6 and B12 deficiency syndrome. It is also indicated in the treatment of Polyneuropathy of any origin such as
- Diabetic, Alcoholic or Toxic neuropathies, Neuritis, Neuralgia, Cervical Syndrome, Lumbago, Sciatica, Myalgia, Intercostal neuralgia, Herpes Zoster, Trigeminal Neuralgia, Supportive treatment in facial paresis.
Dose & Administration:
Ideally, 1 to 3 tablets may be administered per day or as directed by the physician.
NVmet
Composition:
NVmet™ 500 Tablet: Each film coated tablet contains Metformin Hydrochloride BP 500 mg.
NVmet™ 850 Tablet: Each film coated tablet contains Metformin Hydrochloride BP 850 mg.
NVmet™ 500 SR Tablet: Each sustained release tablet contains Metformin Hydrochloride BP 500 mg.
Indication:
NVmet™, as monotherapy, is indicated as an adjunct to diet and exercise to improve glycemic control in patients with type 2 diabetes. NVmet™ is also indicated for use in combination with other agents, that do not result in adequate glycemic control.
Dose and administration:
Diabetes mellitus: Adult and child over 10 years initially 500 mg with breakfast for at least 1 week, then 500 mg with breakfast and evening meal for at least 1
week, then 500 mg with breakfast, lunch and evening meal; usual max. 2 g daily in divided doses.
Polycystic ovary syndrome: initially 500 mg with breakfast for 1 week, then 500 mg with breakfast and evening meal for 1 week, then 1.5-1.7 g daily in 2-3 divided doses or as directed by the physician.
Nortin
Composition:
Nortin™ 10 Capsule: Each capsule contains Nortriptyline Hydrochloride BP equivalent to 10 mg Nortriptyline.
Nortin™ 25 Capsule: Each capsule contains Nortriptyline Hydrochloride BP equivalent to 25 mg Nortriptyline.
Indication:
Depressive illness, Panic disorder & Neuropathic pain.
Dosage & administration:
Depression, low dose initially increased as necessary to 75-100 mg daily in divided doses or as a single dose (max. 150 mg daily);
Adolescent and Elderly patient : 30- 50 mg daily in divided doses. Neuropathic pain, initially 10 mg daily at night, gradually increased if
necessary to 75 mg daily; higher doses under specialist supervision. Or as directed by the physician
Navacef
Composition:
Navacef™ 250 Capsule: Each capsule contains Cefaclor Monohydrate USP equivalent to 250 mg of Cefaclor.
Navacef™ 500 Capsule: Each capsule contains Cefaclor Monohydrate USP equivalent to 500 mg of Cefaclor.
Navacef™ PFS (100 ml): Each 5 ml contains Cefaclor Monohydrate USP equivalent to 125 mg of Cefaclor.
Navacef™ PFS (60 ml): Each 5 ml contains Cefaclor Monohydrate USP equivalent to 125 mg of Cefaclor.
Navacef™ Paediatric Drops (15 ml): Each 1.25 ml contains Cefaclor Monohydrate USP equivalent to 125 mg of Cefaclor
Indication
Respiratory Tract Infections: Pneumonia, bronchitis, pharyngitis, tonsillitis, otitis media.
Uninary Tract Infections: Pylonephritis, cystitis etc.
Skin & Soft Tissue Infections: Impetigo, pyodema, cellulitis, pruritis etc.
Dosage & Administration
Adults: 250 mg three times daily (Dose should be doubled in severe cases, max. 4 g daily). Children
over 1 month: 20 mg/kg/ day in three divided doses (Dose should be doubled in severe cases, max 1
g daily). 1-5 years: 125 mg three times daily, over 5 years: 250 mg three times daily, (Dose should be
doubled in severe cases), or as directed by the physician.
Neparact TS Eye Drops
Composition:
Neparact™ TS Sterile Eye Suspension: Each ml contains Nepafenac INN 3 mg.
Preservative: Sodium Perborate BP 0.001%
Indications:
Neparact™ TS Sterile Eye Suspension is indicated for-
The treatment of post-operative ocular pain and
inflammation including cataract surgery.
Dosage & administration:
•Instill 1 drop once daily 1 day prior to cataract surgery
and continued on the day of surgery and through the
first 2 weeks of the post-operative period.
•An additional drop should be administered 30 to 120
minutes prior to surgery.
Nestor
Composition
Nestor™ 5 Tablet: Each film coated tablet contains Rosuvastatin Calcium BP equivalent to Rosuvastatin 5 mg.
Nestor™ 10 Tablet: Each film coated tablet contains Rosuvastatin Calcium BP equivalent to Rosuvastatin 10 mg.
Indication
Heterozygous Hypercholesterolemia (Familial and Nonfamilial) Homozygous Hypercholesterolemia (Familial) Mixed Dyslipidemia (Fredrickson Type lla and lib)
Dosage & Administration
For asian people, initial starting dose of Rosuvastatin is 5 mg once daily. The dose range of Rosuvastatin is 5-40 mg once daily. Heterozygous Hypercholesterolemia (Familial and Nonfamilial) and Mixed Dyslipidemia (Fredrickson Type lla and lib) The usual recommended starting dose of rosuvastatin is 10 mg once daily. Initiation of therapy with 5 mg once daily may be considered for patients requiring less aggressive LDL-C reductions or who have predisposing factors for myopathy. For patients with marked hypercholesterolemia (LDLC > 190 mg/dL) and aggressive lipid targets, a 20-mg starting dose may be considered. The 40-mg dose of rosuvastatin should be reserved for those patients who have not achieved goal LDL-C at 20 mg. After initiation and/or upon titration of rosuvastatin, lipid levels should be analyzed within 2 to 4 weeks and dosage adjusted accordingly.
Homozygous Hypercholesterolemia (Familial):
The recommended starting dose of rosuvastatin is 20 mg once daily in patients with homozygous FH. The maximum recommended daily dose is 40 mg. Rosuvastatin should be used in these patients as an adjunct to other lipid-lowering treatments (e.g., LDL apheresis) or if such treatments are unavailable. Patients with renal insufficiency: No modification of dosage is necessary for patients with mild to moderate renal insufficiency. For patients with severe renal impairment (CLcr <30 mL/min/1.73 m2) not on hemodialysis, dosing of rosuvastatin should be started at 5 mg once daily and should not be exceeded 10 mg once daily or as directed by the physician.
Navix Plus
Composition:
Navix™ Plus Tablet: Each film coated tablet contains Clopidogrel Bisulfate USP equivalent to Clopidogrel 75 mg and Aspirin BP 75 mg.
Indication:
The preparation is used for the prevention of ischemic events, myocardial infarction, stroke and cardiovascular death in patients with acute coronary syndrome.
Dosage & Administration:
The recommended dose is once daily or as directed by the physician.
Navix
Composition:
Navix™ Tablet: Each film coated tablet contains Clopidogrel Bisulfate USP equivalent to 75 mg Clopidogrel.
Indication:
Clopidogrel is indicated for the reduction of atherosclerotic events (myocardial infarction, stroke and vascular death) and in patient with atherosclerosis documented recent stroke, recent myocardial infarction or established peripheral arterial disease (PAD).
Dosage & Administration:
The recommended dose of Clopidogrel is 75 mg once daily with or without food. No dosage adjustment is required for elderly patients or patients with renal disease or as directed by the physician.
Nafgal
Composition:
Nafgal Cream: Each gram cream contains Naftifine Hydrochloride USP 20 mg.
Indications:
Nafgal Cream is indicated for the treatment of interdigital tinea pedis, tinea cruris and tinea corporis caused by the organism Trichophyton rubrum.
Dosage & Administration:
Apply a thin layer of Nafgal Cream once-daily to the affected areas plus half inch margin of healthy surrounding skin for 2 weeks or as directed by the physician.
