Luliconazole
Composition:
Lulider Cream: Each gram cream contains Luliconazole INN 10 mg.
Pharmacology:
Exact mechanism of action against dermatophytes is unknown.
Luliconazole appears to inhibit ergosterol synthesis by inhibiting
the enzyme lanosterol demethylase. Inhibition of this enzyme’s
activity by azoles results in decreased amount of ergosterol, a
constituent of fungal cell membranes and a corresponding
accumulation of lanosterol.
Indication:
Lulider Cream is indicated for the topical treatment of interdigital
Tinea pedis, Tinea cruris and Tinea corporis, in patients 2 years of
age and older.
Dosage & Administration:
Tinea pedis: A thin layer of cream should be applied to the
affected area and approximately 1 inch of the immediate
surrounding area(s) once daily for two weeks.
Tinea cruris and Tinea corporis: A thin layer of cream, should be
applied to the affected area and approximately 1 inch of the
immediate surrounding area(s) once daily for one week or as
directed by the physician.
Lornoxicam
Composition
Loxodol 4 : Each film coated tablet contains Lornoxicam INN 4 mg.
Loxodol 8 : Each film-coated tablet contains Lornoxicam INN 8 mg.
Pharmacology
Lornoxicam belongs to oxicam group and non-steroidal anti-inflammatory drug (NSAID),
with analgesic, anti-pyretic, anti-thrombotic and anti-inflammatory activities. Upon oral
administration, lornoxicam binds to and inhibits the activity of the cyclooxygenase
enzymes (COX) type 1 (COX-1) and type 2 (COX-2) by the ratio of 1:1. It readily
penetrates into the synovial fluid. This leads to reduced prostaglandin and
thromboxane production and decreased pain, fever and inflammation. Lornoxicam is
well absorbed orally and has half-life of around 3-4 hours. The onset of action can be
observed within 30 to 60 minutes of administration and eliminated via liver and kidneys (
42%).
Indications
Indicated for the treatment of mild to moderate pain in osteoarthritis, surgery, sciatica
and other inflammations.
Dosage & Administration
For Pain relief: In Adult: 8-16 mg daily in 2-3 divided doses. Max: 16 mg daily.
In Osteoarthritis & Rheumatoid arthritis: Adult: 12 mg daily in 2-3 divided doses, up to
16 mg daily if needed.
For patients with renal/liver impairment: Maximum 12 mg daily in 2-3 divided doses.
It should be taken 1 hour before meal or 2 hours after meal to minimize gastrointestinal
irritation or as directed by the physician.
Contraindications
Contraindicated in patients with peptic ulcer, severe kidney impairment and
hypersensitivity. Lornoxicam can increase risk of fatal heart attack or stroke.
Warnings & Precautions
It is not recommended to administer Lornoxicam to patients with history of peptic ulcer,
hypersensitivity, impaired kidney or liver function, high blood pressure, heart failure,
ulcerative colitis or Crohn's disease, asthma and lupus erythematosus, diabetes or
blood coagulation disorder.
Side Effects
The most common side effects are:
Gastrointestinal: Abdominal pain, diarrhea, indigestion, nausea, vomiting, inflammation
of pancreas and mouth ulcer.
Central Nervous System: Headache, drowsiness, sleeplessness and dizziness.
Eye and ENT: Visual disturbance, ringing in ear and sensitivity to light.
Heart: High blood pressure, palpitations and fluid retention.
Skin: Skin rash.
Use in Pregnancy & Lactation
Lornoxicam is not recommended during pregnancy and breastfeeding and is
contraindicated during the last third of pregnancy.
Use in Children & Adolescents
Due to lack of data, Lornoxicam is not indicated for children and adolescents below 18
years old.
Drug Interactions
Combination with Vitamin K antagonists like warfarin increases the risk of bleeding.
Combination with Cyclosporin can lead to reduced kidney function, and to acute kidney
injury in rare cases. Lornoxicam can also increase the adverse effects of lithium,
methotrexate and digoxin and its derivatives. The effect of diuretics, ACE inhibitors and
angiotensin II receptor antagonists can be reduced, in patients with heart failure.
Overdosage
Symptoms: Increased side effects from the central nervous system and gastrointestinal
tract, increased blood pressure, cardiac and / or acute renal failure.
Treatment: Gastric lavage, appointment of activated carbon & monitoring of vital
functions.
Storage
Store below 30°C, away from light and in a dry place. Keep all medicines out of the
reach of children.
Packing:
Loxodol 4 : Each box contains 3 X 10 tablets in Alu-Alu blister & an insert.
Loxodol 8 : Each box contains 3 X 10 tablets in Alu-Alu blister & an insert.
Lactic Acid + Citric Acid + Potassium
Composition:
Feelfree Gel: Each gram gel contains Lactic Acid BP 18 mg, Citric Acid BP 10 mg & Potassium Bitartrate USP 4 mg.
Indication:
Feelfree is indicated for the prevention of pregnancy in female of reproductive potential for use as an on-demand method of contraception.
Dose & Administration:
Administer 5 g gel Feelfree vaginally by the applicator immediately before (or up to one hour before) each episode of vaginal intercourse. May use during any part of the menstrual cycle or as directed by the physicians.
Linagliptin + Metformin
Composition:
Diplin™ M 500 Tablet: Each film coated tablet contains Linagliptin INN 2.5 mg & Metformin Hydrochloride BP 500 mg.
Indications:
Diplin™ M 500 is a dipeptidyl peptidase-4 (DPP-4) inhibitor and biguanide combination product indicated as
an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus when
treatment with both Linagliptin and Metformin is appropriate.
Dose & Administration:
The maximum recommended dose is Linagliptin 2.5 mg/Metformin Hydrochloride 1000 mg twice daily Or as directed by the physician.
Linagliptin
Composition
Diplin 5 Tablet: Each film coated tablet contains Linagliptin INN 5 mg.
Pharmacology
Diplin is a dipeptidyl peptidase-4 (DPP-4) inhibitor, which is believed to exert its actions in patients with type 2 diabetes by slowing the inactivation of incretin hormones. Incretin hormones, including glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), are released by the intestine throughout the day and levels are increased in response to a meal. These hormones are rapidly inactivated by the enzyme, DPP-4. The incretins are part of an endogenous system involved in the physiologic regulation of glucose homeostasis. When blood glucose concentrations are normal or elevated, GLP-1 and GIP increase insulin synthesis and release from
pancreatic beta cells by intracellular signaling pathways involving cyclic AMP. GLP-1 also lowers glucagon secretion from pancreatic alpha cells, leading to reduce hepatic glucose production. By increasing and prolonging active incretin levels, Diplin increases insulin release and decreases glucagon levels in the circulation in a glucose-dependent manner.
Indication
Diplin is indicated as an adjunct to diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus.
Dose & Administration
The recommended dose of Diplin is 5 mg once daily. No dosage adjustment is required for hepatic or kidney impaired patients or as directed by the physician.
Loteprednol Etabonate + Tobramycin
Composition
Loteba™ Sterile Eye Suspension: Each ml contains Loteprednol
Etabonate INN 5 mg and Tobramycin USP 3 mg.
Indications
Loteba™ is indicated for steroid responsive inflammatory ocular conditions for which a corticosteroid is indicated and where superficial bacterial ocular infection or a risk of bacterial ocular infection exists. The use of a combination drug with an anti-infective component is indicated
where the risk of superficial ocular infection is high, where dangerous number of bacteria will be present in the eye.
Dosage and administration
Shake the bottle well before use Apply 1 to 2 drops of Loteba™ into the conjunctival sac of the affected eye (s) every 4 to 6 hours. During the initial 24 to 48 hours, the dosing may be increased, to every 1 to 2 hours. Frequency should be
decreased gradually as warranted by improvement in clinical signs. Care should be taken not to discontinue therapy prematurely or as directed by the physician
Levofloxacin
Composition:
Levoquin TS
Sterile Eye Drops: Each ml contains Levofloxacin Hemihydrate USP equivalent
Levofloxacin 15 mg.
Indications:
Levoquin TS Sterile Eye Drops is indicated for the
treatment of bacterial conjunctivitis caused by susceptible strains of
gram-positive bacteria.
Dosage & Administration:
Levoquin TS Sterile Eye Drops:
Days 1 & 3: Instill 1 drop in the affected eye(s) every 30 minutes to 2 hours while awake per day.
Days 4 to completion: Instill 1 drop in the affected eye(s) every 1-4 hours while awake per day.
or as directed by the physician
Levamlodipine
Composition
L-Amlo 1.25 Tablet:Each tablet contains Levamlodipine Maleate INN equivalent to
Levamlodipine 1.25 mg.
L-Amlo 2.5 Tablet:Each tablet contains Levamlodipine Maleate INN equivalent to
Levamlodipine 2.5 mg.
L-Amlo 5 Tablet:Each tablet contains Levamlodipine Maleate INN equivalent to Levamlodipine
5 mg.
Indication
L-Amlo is a calcium channel blocker which is used alone or in combination with other
antihypertensive agents for the treatment of hypertension. Lowering blood pressure reduces the
risk of fatal and nonfatal cardiovascular events, primarily strokes and myocardial infarctions.
Dose & Administration
Adult recommended dose: 2.5 mg orally once daily with maximum dose 5 mg once daily. For small, fragile or elderly patients or patients with hepatic insufficiency, 1.25 mg once daily starting dose is recommended.
Paediatric starting dose: 1.25 mg to 2.5 mg once daily or as directed by the physicians
