Human Health Division (HHD) Products

Veterinary Division (VET)
Product List by Generic Name
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Nabumeton

Composition : Nabuton 500 Tablet: Each film coated tablet contains Nabumetone BP 500 mg. Nabuton 750 Tablet: Each film coated tablet contains Nabumetone BP 750 mg.

Pharmacology: Nabumetone is a non-steroidal anti-inflammatory drug (NSAID) that exhibits anti-inflammatory, analgesic and antipyretic properties in pharmacological studies. As with other non-steroidal anti-inflammatory agents, it's mode of action is not known; however, the ability to inhibit prostaglandin synthesis may be involved in the anti-inflammatory effect. The active ingredient is a prodrug, which undergoes hepatic biotransformation to the active component, 6-methoxy-2-naphthylacetic acid (6MNA), that is a potent inhibitor of prostaglandin synthesis.

Indication: Nabuton tablet is indicated for acute and chronic treatment of signs and symptoms of osteoarthritis and rheumatoid arthritis.

Dose & Administration :Osteoarthritis and Rheumatoid arthritis: The recommended starting dose is 1000 mg taken as a single dose with or without food. Some patients may obtain more symptomatic relief from 1500 mg to 2000 mg per day. Nabumetone can be given in either a single or twice-daily dose. Dosage greater than 2000 mg per day have not been studied. The lowest effective dose should be used for chronic treatment. Caution should be used in prescribing Nabumetone to patient with moderate or severe renal insufficiency. The maximum starting dose of Nabumetone in patients with moderate or severe renal insufficiency should not exceed 750 mg or 500 mg, respectively once daily. Following careful monitoring of renal function in patients with moderate or severe renal insufficiency, daily doses may be increased to a maximum of 1500 mg and 1000 mg, respectively or as directed by the physicians.

Contraindication : Hypersensitivity  NSAID induced asthma, urticaria or other allergic type reactions. 

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Naviscon Sodium Alginate BP, Sodium Bicarbonate BP & Calcium Carbonate USP

Composition
Naviscon Suspension: Each 10 ml suspension contains Sodium Alginate BP 500 mg, Sodium Bicarbonate BP 267 mg & Calcium Carbonate USP 160 mg. Naviscon Chewable Tablet: Each chewable tablet contains Sodium Alginate BP 250 mg, Sodium Bicarbonate BP 133.5 mg & Calcium Carbonate USP 80 mg.

Pharmacology

The mode of action of the product is non-systemic and does not depend on absorption into the systemic circulation. On ingestion, the product reacts rapidly with gastric acid to form a raft of Alginic acid gel having a near-neutral pH and which floats on the stomach contents quickly and effectively impeding gastro-esophageal reflux, for up to 4 hours. In severe cases, the raft itself may be refluxed into the esophagus in preference to the stomach contents and exert a demulcent effect. Indications Naviscon is indicated for the treatment of heartburn, heartburn of pregnancy, dyspepsia associated with gastric reflux, hiatus hernia, reflux esophagitis, regurgitation and all cases of epigastric and retrosternal distress where the underlying cause is gastric reflux.

Dosage & Administration
 Naviscon Suspension: Adult and children over 12 years: 10-20 ml after meals and at bedtime, up to four times a day. Children 6 to 12 years: 5-10 ml after meals and at bedtime, up to four times a day. Children under 6 years: Not recommended. shake well before each use. Chewable Tablet: Adult and children over 12 years: 2-4 tablets after meals and at bedtime, up to four times a day. Children under 12 years: Should be given only on doctor advice. Elderly: No dosage modification is required for this age group. Hepatic Impairment: No dose modification necessary.

 Contraindication

This product is contraindicated in patients with known or suspected hypersensitivity to the active ingredients or to any of the excipients.

Warnings & Precautions

If symptoms do not improve after 7 days, the clinical situation should be reviewed. This should be taken into account when a highly restricted salt diet is recommended e.g. in some cases of congestive cardiac failure and renal impairment. Care needs to be taken in treating patients with hypercalcaemia, nephrocalcinosis and recurrent calcium containing renal calculi.

Side Effects

 In addition to the desired effect of the drug, some side effects may appear such as constipation, flatulence, stomach cramp or belching. If too big dose has been taken, there might appear a sensation of swelling in stomach. In these cases consult a physician.

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Nortripline

Composition:
Nortin™ 10 Capsule: Each capsule contains Nortriptyline Hydrochloride BP equivalent to 10 mg Nortriptyline.
Nortin™ 25 Capsule: Each capsule contains Nortriptyline Hydrochloride BP equivalent to 25 mg Nortriptyline.

Indication:
Depressive illness, Panic disorder & Neuropathic pain.

Dosage & administration:
Depression, low dose initially increased as necessary to 75-100 mg daily in divided doses or as a single dose (max. 150 mg daily);
Adolescent and Elderly patient : 30- 50 mg daily in divided doses. Neuropathic pain, initially 10 mg daily at night, gradually increased if
necessary to 75 mg daily; higher doses under specialist supervision. Or as directed by the physician

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Naproxen + Esomeprazole

Composition
Esona™ 375/20 Tablet: Each tablet contains Naproxen BP 375 mg & Esomeprazole Magnesium Trihydrate USP equivalent to Esomeprazole 20 mg.
Esona™ 500/20 Tablet: Each tablet contains Naproxen BP 500 mg & Esomeprazole Magnesium Trihydrate USP equivalent to Esomeprazole 20 mg.

Indication
It is indicated for the relief of signs and symptoms of osteoarthritis, rheumatoid arthritis and ankylosing spondylitis, dysmenorrhoea and to decrease the risk of developing gastric ulcers in patients at risk of developing NSAID associated gastric ulcers.

Dosage and Administration
Carefully consider the potential benefits and risks of Esona™ and other treatment options before deciding to use Esona™. Use the lowest effective dose for the shortest duration consistent with individual patient treatment goals. If a dose of Esomeprazole lower than a total daily dose of 40 mg is more appropriate, a different treatment should be considered.

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Nepafenac

Composition:
Neparact™ TS Sterile Eye Suspension: Each ml contains Nepafenac INN 3 mg.
Preservative: Sodium Perborate BP 0.001%

Indications:
Neparact™ TS Sterile Eye Suspension is indicated for-
The treatment of post-operative ocular pain and
inflammation including cataract surgery.

Dosage & administration:
•Instill 1 drop once daily 1 day prior to cataract surgery
and continued on the day of surgery and through the
first 2 weeks of the post-operative period.
•An additional drop should be administered 30 to 120
minutes prior to surgery.

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Naftifine

Composition:
Nafgal Cream: Each gram cream contains Naftifine Hydrochloride USP 20 mg.

Indications:
Nafgal Cream is indicated for the treatment of interdigital tinea pedis, tinea cruris and tinea corporis caused by the organism Trichophyton rubrum.

Dosage & Administration:
Apply a thin layer of Nafgal Cream once-daily to the affected areas plus half inch margin of healthy surrounding skin for 2 weeks or as directed by the physician.

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