Human Health Division (HHD) Products
Product List by Brand Name
CVnor A
Composition
CVnor A: Each tablet contains Amlodipine Besilate BP equivalent to
Amlodipine 5 mg and Atenolol BP 50 mg.
Pharmacology
CVnor A is a fixed dose combination of Amlodipine and Atenolol. Amlodipine
is a dihydropyridine calcium antagonist that inhibits the transmembrane influx of
calcium ions into vascular smooth muscle and cardiac muscle; it has a greater
effect on vascular smooth muscle cells than cardiac muscle cells. Amlodipine is
a peripheral vasodilator that acts directly on vascular smooth muscle to cause a
reduction in peripheral vascular resistance and reduction in blood pressure.
Amlodipine reduces tone, decreases coronary vasoreactivity and lowers
cardiac demand by reducing after load. Atenolol is a cardio-selective beta-blocker. It does not possess any membrane-stabilizing action. The cardio selectivity is dose related. Atenolol causes a reduction in blood pressure by lowering cardiac output, decreasing the plasma renin activity and sympathetic outflow from CNS. Atenolol also causes a reduction in myocardial oxygen
demand by virtue of its negative inotropic and negative chronotropic effect.
Indication
Hypertension is not controlled by monotherapy, patients with angina pectoris and hypertension as co-existing diseases; post myocardial infarction, refractory angina pectoris where nitrate therapy has failed.
Dose & Administration
Initially, 1 tablet daily. If necessary, the dose may be increased to 2 tablets daily.
Elderly patients or patients with hepatic impairment ½ tablet daily. The dosage,
however, should be individualized or as directed by the physician.
Clonipres ER
Composition
Clonipres ER 0.1 Tablet: Each Extended release tablet contains Clonidine Hydrochloride USP 0.1 mg.
Indications
Clonidine hydrochloride extended release tablet is indicated for the treatment of attention deficit hyperactivity disorder (ADHD) as monotherapy.
Dosage and Administration
Attention deficit hyperactivity disorder : Clonidine ER
0.1 mg/day for 8 weeks
Chewce
Administration:
Maybe taken with or without food
Mode of Action
Vitamin C: Necessary for collagen formation and tissue repair; plays a role in oxidation/reduction reactions as well as other metabolic pathways including synthesis of catecholamines, carnitine, and steroids; also plays a role in conversion of folic acid to folinic acid.
Precaution
Should be given with caution to patient with hyperoxaluria.
Side Effect
Flushing, Flank pain, Faintness, headache, Diarrhea, dyspepsia, nausea, vomiting, Hyperoxaluria (large doses)
Interaction
Vit C: Deferroxamine, hormonal contraceptives, flufenazine, warfarin, elemental iron, salicylates, warfarin, fluphenazine, disulfiram, mexiletine, vitamin B12.
Clascon
Composition:
Clascon cream: Each gram cream contains Clascoterone INN 10 mg.
Indication:
Clascon cream is indicated for the topical treatment of acne vulgaris in patients of 12 years of age and older.
Dose & Administration:
Clean the affected area gently then apply a thin uniform layer of Clascon cream twice per day in the morning and evening to the affected area. Avoid accidental transfer of Clascon cream into eyes, mouth or other mucous membranes. If contact with mucous membranes occurs, this should be rinsed thoroughly with water or as directed by the physician.
Curafin
Composition:
Curafin Cream: Each gram cream contains Amorolfine Hydrochloride BP equivalent to Amorolfine 2.5 mg.
Indication:
Curafin Cream is indicated for the treatment of Tinea pedis (athlete's foot), Tinea cruris, Tinea inguinalis,Tinea corporis,Tinea manuum & Pityriasis versicolor.
Dose & Administration:
To be applied to affected skin areas once daily following cleansing (in the evening).The treatment should be continued without interruption until clinical cure, and for 3 -5 days
thereafter. The required duration of treatment depends on the species of fungi and on the localization of the infection. In general, treatment should be continued for at least two
to three weeks. With foot mycoses, up to six weeks of therapy may be necessary or as directed by the physicians
Conpan
Composition
Conpan ODT 0.5 : Each orally disintegrating tablet contains Clonazepam USP 0.5 mg.
Conpan ODT 1 : Each orally disintegrating tablet contains Clonazepam USP 1 mg.
Conpan ODT 2 : Each orally disintegrating tablet contains Clonazepam USP 2 mg.
Indications
Clonazepam is indicated in all forms of epilepsy, status epilepticus, infantile spasms,
myoclonic seizures, akinetic and atonic seizures, partial seizures, bipolar affective
disorder, panic attacks etc.
Dosage & Administration
The standard dose of clonazepam must be individually adjusted according to the patient's
clinical response and tolerance of the drug. As a general rule, Clonazepam is started with
low single dose in a new patient. Adults: 1mg (elderly, 0.5 mg), initially at night for 4
nights, increased according to response over 2-4 weeks to usual maintenance dose of 4-8
mg which is usually given at night as a single dose or may be given in 3-4 divided doses if
necessary. Children: Up to 1 year, initially 0.25 mg, increased as above to usual
maintenance dose of 0.5-1 mg, 1-5 years initially 0.25 mg, increased as above to 1-3 mg,
5-12 years, initially 0.5 mg, increased as above to 3-6 mg.
Direction for administration of Conpan Orally Disintegrating Tablet:
This tablet must be handled with dry hand. The tablet to be placed on tongue and let it be
dissolved. It should not be chewed, broken, or crushed. Like other conventional oral
tablets, it also can be swallowed with a glass of water or as directed by the physician.
Clonipres
Composition
Clonipres™ 0.1 Tablet: Each tablet contains Clonidine Hydrochloride USP 0.1 mg.
Indication
Clonidine is indicated in the treatment of hypertension. It may be employed alone or
concomitantly with other anti-hypertensive agents.
Other uses include:
i) Menopausal flushing
ii) Attention deficit hyperactivity disorder
iii) Opioid withdrawal & Alcohol withdrawal syndrome
iv) Tourette's syndrome
Dosage & Administration
Adult: The dose of Clonidine must be adjusted according to the patient's individual blood
pressure response.
Initial dose: 0.1 mg twice a day (morning & bed time). Elderly patients may be benefited
from a lower initial dose.
Maintenance dose: Further increments of 0.1 mg per day may be made at weekly
intervals if necessary, until the desired result is achieved. The therapeutic dose most
commonly employed have ranged from 0.2 mg to 0.6 mg per day given in divided doses.
In renal impairment, dose of Clonidine Hydrochloride must be adjusted according to the
degree of impairment & patient should be monitored carefully.
Menopausalflushing :0.1 mg to 0.4 mg daily
Attention deficit hyperactivity disorder :5 mcg/kg/day for 8 weeks
Alcohol withdrawal :0.3 to 0.6 mg every 6 hourly
Tourette's syndrome / 0.15 mg to 0.2 mg daily or as directed by the physician
Cinagen-D Eye Drops
Composition:
Cinagen™-D Sterile Eye Drops: Each ml contains Moxifloxacin
Hydrochloride BP equivalent to Moxifloxacin 5 mg and Dexamethasone Sodium Phosphate USP equivalent to Dexamethasone Phosphate 1 mg.
Preservative: Sodium Perborate BP 0.001%.
Indications:
Cinagen™-D Sterile Eye Drops is indicated for the treatment of eye infections caused by susceptible microorganisms and prevention of inflammation and bacterial infection occurred after ocular surgery.
Dosage and administration:
In the prevention of infection and postoperative ocular inflammation, instill 1 drop 4 times per day. Frequency should be decreased gradually with improvement of clinical signs or as directed by the physician.
Cinagen Eye Drops
Composition
Cinagen™ Sterile Eye Drops: Each ml contains Moxifloxacin Hydrochloride BP equivalent to Moxifloxacin 5 mg.
Indications
Cinagen™ is indicated for the treatment of bacterial conjunctivitis caused by susceptible strains of following organisms:
Aerobic gram-positive microorganism: Corynebacterium species, Micrococus luteus, Staphylococcus aureus, Staphylococus epidermis, Staphylococus haemolyticus, Staphylococcus hominis, Staphylococcus warneri, Streptococcus pneumoniae, Streptococcus viridans group Aerobic Gram-negative microorganisms: Acinetobacter iwoffi, Haemophilusinfluenzae, Haemophilus parainfluenzae.
Dosage and administration
Cinagen™ Sterile Eye Drops: One drop in the affected eyes 3 times per day for 7 days or as directed by the physician.
Cfresh Liquigel Eye Drops
Presentation
Cfresh™ Liquigel: Each ml Sterile lubricant eye drops
contain Carboxymethylcellulose Sodium USP 10 mg.
Preservative: Sodium Perborate 0.001%
Indications
It is indicated for use as a lubricant in dry eye
(keratoconjunctivitis sicca) including relief of burning,
irritation and/or discomfort due to dryness of the eye.
Dosage and Application
Instill 1 or 2 drops in the affected eye(s) or as directed by the physician.
