Human Health Division (HHD) Products
Product List by Brand Name
Vontac Tablet
Composition
Vontac 10: Each film coated tablet contains Vonoprazan fumarate INN equivalent
to Vonoprazan 10 mg.
Vontac 20: Each film coated tablet contains Vonoprazan fumarate INN equivalent
to Vonoprazan 20 mg.
Pharmacology
Vonoprazan is a novel potassium-competitive acid blocker (P-CAB) that works through a
reversible potassium-specific competitive mechanism to inhibit active proton pumps
directly. Vonoprazan does not require acid activation or any time constraints for its
administration. As a result of its rapid onset and prolonged action, Vonoprazan is a
suitable option for PPI.
Vonoprazan can be taken regardless of meal ingestion and the rate of absorption is not
affected by meals. The absorption speed of Vonoprazan is rapid, and the time taken to
reach maximum concentration in plasma is less than 2 hours after oral administration.
After absorption, the T1/2 in plasma is approximately 2 hours for conventional PPIs, but
up to 9 hours for vonoprazan. Therefore, Vonoprazan stays in the blood longer and can
block acid secretion continuously.
Indication
• Treatment of gastric ulcer, duodenal ulcer, reflux esophagitis; prevention of recurrent
gastric or duodenal ulcer associated with low-dose aspirin administration; and
prevention of recurrent gastric or duodenal ulcer associated with non-steroidal
anti-inflammatory drug administration
• Adjunct therapy to Helicobacter pylori eradication in the following: Gastric or duodenal
ulcer, Gastric Mucosa Associated Lymphoid Tissue (MALT) lymphoma, idiopathic
thrombocytopenic purpura, the stomach after endoscopic resection of early-stage gastric
cancer, or Helicobacter pylori gastritis.
Dosage & Administration
• Gastric ulcer & duodenal ulcer: The usual adult dosage is 20 mg once daily, 8 week
treatment for gastric ulcer and a 6-week treatment for duodenal ulcer.
• Reflux esophagitis: The usual adult dose is 20 mg once daily for a total of 4 weeks of
treatment. If that dosing proves insufficient, the administration should be extended, but
for no longer than 8 weeks of treatment.
• For the maintenance therapy of reflux esophagitis showing recurrence. The dose is 10
mg once daily. When the efficacy is inadequate, the dosage may be increased up to 20
mg once daily.
• Prevention of recurrence of gastric or duodenal ulcer during low-dose aspirin
administration: The usual adult dose is 10 mg once daily.
• Prevention of recurrence of gastric or duodenal ulcer during non-steroidal
anti-inflammatory drug (NSAID) administration: The usual adult dose is 10 mg once
daily.
• Adjunct to Helicobacter pylori eradication: For adults, the following three-drug regimen
should be administered orally at the same time twice daily for seven days: 20 mg dose
of Vonoprazan, 750 mg dose of amoxicillin hydrate and 200 mg dose of clarithromycin.
• If Helicobacter pylori eradication with a three-drug regimen comprising a proton pump
inhibitor, amoxicillin hydrate and clarithromycin has been unsuccessful, as an alternative
treatment, adults should be administered the following three drugs twice daily for seven
days: 20 mg of Vonoprazan, 750 mg of amoxicillin hydrate and 250 mg of Metronidazole
or as directed by the physicians.
Vomitop
Composition:
Vomitop Tablet: Each film coated tablet contains Domperidone maleate BP equivalent to 10 mg Domperidone.
Indication:
Prevention & symptomatic relief of acute nausea and vomiting of adults (from any cause specially due to cytotoxic therapy & radiotherapy). Nausea & vomiting associated with L-dopa and bromocriptine treatment for parkinsonian patients. Nausea & vomiting due to migraine, head injury, pancreatitis, gastritis, hepatitis, post-gastrectomy syndrome, haemodialysis and dysmenorrhoea. Non ulcer dyspepsia, oesophageal reflux, reflux oesophagitis & gastritis.
Speeding of barium transit in 'follow through' radiological studies.
Dose & Administration:
Adult & Elderly patients: 10-20 mg every 4-8 hours. Domperidone should be taken 15-30 minutes before meal or as directed by the physician.
Vitared
Composition:
Each capsule contains Ascorbic Acid BP (Vitamin C) 60 mg, Alpha Tocopheryl Acetate BP (Vitamin E) 30 mg, Zinc (as Zinc Oxide BP) 15 mg, Copper (as Cupric Oxide BP) 2 mg & Lutein BP 6 mg.
Indication:
Vitared is indicated for Age Related Eye Diseases (ARED) e.g. Age Related Macular Degeneration (ARMD) & cataract.
Dose and Administration:
1-2 capsules/day or as directed by the physician.
