Mirogabalin
Composition
Neumir 2.5 Tablet : Each film coated tablet contains Mirogabalin Besylate INN equivalent to Mirogabalin 2.5 mg
Neumir 5 Tablet : Each film coated tablet contains Mirogabalin Besylate INN equivalent to Mirogabalin 5 mg
Neumir 10 Tablet : Each film coated tablet contains Mirogabalin Besylate INN equivalent to Mirogabalin 10 mg
Indications
Peripheral neuropathic pain including:
• Diabetic peripheral neuropathy
• Post-herpetic neuralgia
• Spinal pain
Dosage and Administration
Normally, the initial dose for adults is 5 mg of Mirogabalin given orally twice daily and then the dose may be gradually increased by 5 mg at an interval of at least a week to 15 mg, given orally twice daily. A dose may be adjusted appropriately between 10 mg and 15 mg depending on ages and symptoms, taken twice daily or as directed by the physician. Mirogabalin can be taken with or without food. If the patient misses a dose, he/she must take the missed dose as soon as possible. If it is almost time for the next dose, the patient should skip the missed dose and continue his/her regular dosing schedule.
Mirogabalin dosage adjustment based on renal function: No dose adjustment is recommended in mild renal impairment. Dose to be reduced to 50% in moderate renally impaired patients. A dose reduction of up to 75% required in patients with severe renal impairment and End-Stage Renal Disease.
Degree of Renal Dysfunction (Clcr: mL/min)
Mild Moderate Severe (including hemodialysis patients)
(90 > Clcr ≥ 60) (60 > Clcr ≥ 30) (30 > Clcr)
Daily dose 10 - 30 mg 5 - 15 mg 2.5 - 7.5 mg
Initial dose 5 mg twice daily 2.5 mg twice daily 2.5 mg once daily
Effective dose-
Minimum dose 10 mg twice daily 5 mg twice daily 5 mg once daily
Recommended-
dose 15 mg twice daily 7.5 mg twice daily 7.5 mg once daily
Ketorolac
Composition:
OrcTM Tablet: Each film coated tablet contains Ketorolac Tromethamine USP 10 mg.
OrcTM 30 IV/IM injection: Each 1 ml ampoule contains Ketorolac Tromethamine USP 30 mg.
OrcTM 60 IV/IM injection: Each 2 ml ampoule contains Ketorolac Tromethamine USP 60 mg.
Indication:
OrcTM tablets are indicated for short term management of moderate postoperative pain and acute & chronic musculoskeletal pain as a continuation of treatment.
OrcTM injections are indicated for short term management of moderate to serve acute post-operative pain.
Dose & Administration:
OrcTM tablets: Ketorolac Tromethamine 10 mg tablet 4-6 hourly; Elderly 6-8 hourly. Maximum dose is 40 mg daily.
OrcTM Injection: Adult patient (<65 years): Ketorolac Tromethamine is for administration by intramuscular or intravenous injection. Initial dose is 60 mg IM or 30 mg IV. Maintenance dose is 30 mg IM/IV 6 hourly.
