Ibandronic Acid

Composition Droniva Tablet: Each film coated tablet contains Ibandronate Monosodium Monohydrate INN equivalent to Ibandronic Acid 150 mg.

Pharmacology: The action of Ibandronic Acid on bone tissue is based on its affinity for hydroxyapatite which is part of the mineral matrix of bone. Ibandronic Acid inhibits osteoclast activity and reduces bone resorption and turnover.

Indications: Droniva is indicated for the treatment and prevention of osteoporosis in postmenopausal women. Droniva increases bone mineral density (BMD) and reduces the incidence of vertebral fractures

 Dosage & Administration: The dose of Droniva is one 150 mg tablet once monthly on the same date of each month or as directed by the physician

Contraindication : Ibandronic Acid is contraindicated in any patient who has shown a hypersensitivity reaction to the drug or to any of the excipients, hypocalcemia and inability to stand or sit upright for at least 1 hour. Warnings & Precautions Hypocalcemia and other disturbances of bone and mineral metabolism should be effectively treated before starting therapy with Ibandronic Acid. Adequate intake of calcium and vitamin D is important in all patients. It is not recommended for use in patients with severe renal impairment (creatinine clearance <30 ml/min).

Side Effects :The most common side effects include back pain, allergic reaction, dyspepsia, diarrhoea, nausea, vomiting, gastritis, myalgia, headache, dizziness, vertigo etc. Use in Pregnancy & Lactation Use in pregnancy: Pregnancy Category C. There are no adequate and well-controlled studies in pregnant women. It should be used during pregnancy only if the potential benefit justifies the potential risk to the mother and foetus. Use in lactating mothers: It is not known whether it is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when it is administered to a lactating woman. Use in Children & Adolescant Safety and effectiveness in paediatric patients have not been established. Use in special groups Geriatric use: No overall differences in effectiveness or safety were observed between elderly patients and younger patients. Therefore, no dosage adjustment is necessary in the elderly. Hepatic Insufficiency: No studies have been performed to assess the pharmacokinetics of Ibandronic Acid in patients with hepatic impairment because lbandronic Acid is not metabolized in the human liver. Renal Insufficiency: It is not recommended for use in patients with severe renal impairment (creatinine clearance of < 30 ml/min).

Glucosamine Sulfate Potassium Chloride & Chondroitin Sulfate Sodium

Composition

Bondro Tablet: Each tablet contains Glucosamine Sulfate Potassium Chloride USP equivalent to Glucosamine Sulfate 750 mg and Chondroitin Sulfate Sodium USP equivalent to Chondroitin Sulfate 600 mg.

Pharmacology

Bondro tablet is a balanced combination of two leading natural supplements of healthy cartilage - Glucosamine and Chondroitin. Glucosamine is a naturally occurring amino sugar of cartilage that provides the basic raw material needed by the body to manufacture joint cartilage. Chondroitin is another naturally occurring mucopolysaccharide of cartilage that stimulates cartilage production, inhibits cartilage destroying enzymes, draws fluid to the cells and helps to lubricate the joints. They work synergistically together to stimulate the production and regeneration of connective tissues (e. g. cartilage, bone, tendon, skin, mucous membrane, blood vessels etc.).

Indication

Indicated for the treatment of osteoarthritis of knee, hip, spine, hand and other locations as a dietary supplement. It is also beneficial in rheumatoid arthritis, sport injuries, migraine, different skin problems (e.g. psoriasis), vascular complications (e.g. atherosclerosis), kidney stones and inflammatory bowel disease (e.g. ulcerative colitis, leaky gut syndrome).

Dose & Administration

1 tablet two times daily or as directed by the physician. Contraindication There is no known contraindication for Glucosamine and Chondroitin. But proven hypersensitivity (e.g. allergic to shellfish or sulfur) to Glucosamine and Chondroitin is a contraindication.

Warning & Precaution

Diabetic patients are advised to monitor blood glucose levels regularly while taking Glucosamine. No special studies were formed in patient with renal and hepatic insufficiency. The toxicological and pharmacokinetic profile of the product does not indicate limitations for these patients. However, administration to these patients with severe hepatic or renal insufficiency should be under appropriate medical supervision.

Side Effects

Both Glucosamine and Chondroitin Sulfates are virtually non-toxic. Side effects are rare and are limited to stomach upset, nausea or diarrhea. These usually disappear when the tablet is taken with meals.

Use In Pregnancy & Lactation

Women who are pregnant or who could become pregnant should not be supplemented with Glucosamine and Chondroitin. These are not been studied enough to determine their effects on a developing fetus and no studies have evaluated the use of Glucosamine and Chondroitin during pregnancy or lactation. It should be taken with caution and medical advice during pregnancy and lactation.

Use In Children & Adolescents

Safety and efficacy in children below 12 years of age have not been established. Drug interactions There has been no reports of significant drug interactions of Glucosamine with anti-biotics, anti-depressants, anti-hypertensives, nitrates, anti-arrythmics, anxiolytic, hypoglycemic agents, anti-secretives. But in case of Chondroitin there is a chance of drug interaction with blood-thinning medications (e.g. warfarin, heparin).

Overdosage

Overdose may cause diarrhea. Storage Store below 30°C., away from light and in a dry place. Keep all medicines out of the reach of children.

Packing

Bondro Tablet: Each box contains 5 X 6 tablets in Alu-Alu blister pack and an insert

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