Calcium Carbonate + Vitamin D3

Introduction

Miracal-D is a prescription medicine. It is a combination of medicines that are prescribed to treat osteoporosis. It ensures the proper growth and functioning of the joints and bones. Miracal-D should be used in the dose and duration as prescribed by your doctor. It is advised to take this medicine at a fixed time. This medicine should not be taken in more than the recommended dose. This is usually a safe medicine with very minimal side effects but if you experience severe diarrhea, nausea, or vomiting or any symptoms of an allergic reaction, please consult your doctor. Before taking this medicine, tell your doctor if you have any other health conditions. Inform your doctor if you are taking any other medicines or if you are pregnant or breastfeeding.

Uses of Miracal-D

• Nutritional deficiencies

Pharmacology

Miracal-D is a combination of two nutritional supplements: Calcium and Vitamin D3 which replenish the body's stores of important nutrients.

Potassium Citrate BP 30% & Citric Acid Monohydrate BP 5%

Composion:
KcitTM 200 ml oral solution: Each 5 ml solution contains Potassium Citrate BP 1500 mg and Citric Acid Monohydrate BP 250 mg

Pharmacology:
Potassium Citrate and Citric Acid Monohydrate oral solution is a stable and pleasant-tasting oral systemic alkalizer. Potassium Citrate is absorbed and metabolized to Potassium Bicarbonate, thus as a systemic alkalizer. This product alkalinizes the urine without producing a systemic alkalosis in recommended doses. Potassium Citrate does not neutralize the gastric juice or disturb digestion.

Indications:
- To relieve discomfort in urinary tract infections
-To prevent kidney stone With uricosuric agent to prevent gout 
- Acidosis caused by kidney diseases

Dose & Administration By mouth using oral solution Adult: 10 mL 3 times a day, diluted well with water Or as directed by the physician.

Magnesium Oxide

Indications

Magnesium Oxide is indicated in-

• Relieving the symptoms of magnesium deficiency.
• Rapid or irregular heart rate, heart attack, angina pectoris, mild or severe hypertension.
• Tetania, muscle cramp, gastrointestinal cramps, stress, increased stimulability of muscles and nerves, call cramps, and cramp in newborn and young children.
• Gynecological diseases, cervical insufficiency, eclampsia, pre-eclampsia, tocolysis, dysmenorrhea.
• Calcification and ossification
• Prevention of kidney stone formation
• Diabetes treatment and migraine

Pharmacology

Magnesium belongs to the group of drugs called mineral support products. It occurs in nature in the form of the mineral periclase. Magnesium is required for energy production, oxidative phosphorylation, and glycolysis. In its purest form, magnesium oxide is a colorless or white crystalline material or very fine powder, with no odor and a bitter taste.

Magnesium helps to regulate diverse biochemical reactions in the body, including protein synthesis, muscle and nerve function, blood glucose control, and blood pressure regulation. It contributes to the structural development of bone and is required for the synthesis of DNA, RNA, and the antioxidant glutathione. Magnesium also plays a role in the active transport of calcium and potassium ions across cell membranes, a process that is important to nerve impulse conduction, muscle contraction, and normal heart rhythm.

Excretion

 The majority of magnesium is excreted renally.

Dosage & Administration

The recommended daily dose for adults and adolescents (12-17 years) is 1-2 tablets.

Interaction

Aminoquinolones, Nitrofurantoin, Penicillamine, Tetracyclines, Fluoroquinolones, Digoxin, Lithium, Sodium polystyrene sulfonate, Nifedipine etc.

Contraindications Hypersensitivity and severe renal impairment.

Side Effects

• Stomach upset and diarrhea
• Hypermagnesaemia
• Paralytic ileus
• Hyper-excitability
• Muscle weakness
• Sleepiness
  
  

Pregnancy & Lactation

It should be used as directed by the physician during pregnancy and lactation.

Precautions & Warnings 
Before taking a magnesium supplement, tell your doctor or pharmacist if you are allergic to it.

Overdose Effects

Symptoms of overdose may include slow heartbeat, severe dizziness, confusion, muscle weakness, loss of consciousness, diarrhea and hypermagnesemia.

Therapeutic Class

Antacids, Electrolytes preparations, Oral electrolytes preparations

Storage Conditions

Keep out of reach of children. Store in a dry place, below 25°C temperature, and protected Irom light.

Ascorbic Acid

Administration:
Maybe taken with or without food

Mode of Action

Vitamin C: Necessary for collagen formation and tissue repair; plays a role in oxidation/reduction reactions as well as other metabolic pathways including synthesis of catecholamines, carnitine, and steroids; also plays a role in conversion of folic acid to folinic acid.

Ferric Maltol

Composition Malifa 30:
Each capsule contains Ferric Maltol INN equivalent to Iron 30 mg.

Pharmacology
Ferric Maltol delivers iron for uptake across the intestinal wall and transfers to transferrin and ferritin. It has been shown to increase serum iron parameters, including ferritin and transferrin saturation. Ferric Maltol dissociates upon uptake from the Gastrointestinal Tract allowing iron and maltol to be absorbed separately. The iron is absorbed across the intestinal wall and transfer to transferrin and ferritin. It increases serum iron parameters, including ferritin and transferrin saturation. Total serum iron peak values were reached 1.5 to 3 hours after administration. Food has been shown to decrease the bioavailability of iron after administration of ferric maltol. Around 60% of ferric maltol is excreted in the urine as glucuronide conjugate. Iron and ferric maltol are not excreted in the urine and unabsorbed ferric maltol is eliminated in the feces.

 Indications
It is indicated for the treatment of iron deficiency in adults.

Dosage & Administration 
 30 mg twice daily on an empty stomach (Morning & Evening). • Continue as long as necessary to replenish body iron stores or as directed by the physician.

Contraindications
It is contraindicated in patients with a history of: • Hypersensitivity to the active substance or to any of the excipients. • Hemochromatosis and other iron overload syndromes • Receiving repeated blood transfusions.

Warnings & Precautions
Avoid use of Ferric Maltol in patients with an active inflammatory bowel disease (IBD) flare, as there is potential risk of increased inflammation in the gastrointestinal tract. • Excessive therapy with iron drugs can lead to excess storage of iron with the possibility of iatrogenic hemosiderosis. • Accidental overdose of iron-containing drugs is a leading cause of fatal poisoning in children under 6 years.

Side Effects
The most common side effects include gas, diarrhoea, constipation, discolored stools, stomach pain, nausea or vomiting and stomach area discomfort or bloating.

Use in Pregnancy & Lactation
In a clinical study, it has been found that oral use of Ferric Iron in pregnant women indicate no malformative nor feto toxicity. Ferric Maltol may be considered during pregnancy if necessary. There is no effects of oral Ferric Iron in breastfeed newborns or infants of treated mother. Ferric Maltol can be used during breastfeeding if clinically needed.
Use in Children & Adolescents
Safety and effectiveness of Ferric Maltol have not been established in paediatric patients.

Drug Interactions
Dimercaprol: Concomitant use of iron products with dimercaprol may increase the risk of nephrotoxicity. The absorption of certain oral medications decreases such as bisphosphonates, levodopa, thyroid medications and tetracycline antibiotics when given together with iron.

Overdosage
Early signs and symptoms of iron overdosage may include nausea, vomiting, abdominal pain and diarrhoea. In more serious cases, hypoperfusion, metabolic acidosis and systemic toxicity are observed. Dosages of excess iron may lead to hemosiderosis.

Storage
Store below 30°C, away from light and in a dry place. Keep all medicines out of reach of children.

Vit B1 + Vit B6 + Vit B12

Calcium (Coral) + Vitamin D3

Ferric Iron (As Ferric Citrate)

Zinc + Copper + Lutein+ Vitamin C + Vitamin E